Bissau is the capital and largest city in the country. Petty crime and incidental exposure to social unrest are the main threats workforce may face. The political environment is volatile and requires close monitoring prior to travel.

The city is located on the West African coast where the Atlantic Ocean meets the Geba River. Avenida dos Combatentes de Liberdade da Patria is the main thoroughfare in the city, it connects Osvaldo Vieira International Airport (OXB) to Bissau Velho (Old City) and the city's port known as Porto Pidjiguiti. Diplomatic compounds and international organisations are largely based in Bairro Penha.